Professor McCaskie is an orthopaedic surgeon with an interest in lower limb surgery e.g. hip arthroscopy and related research. His research aims to develop innovative solutions, particularly regenerative, for patient benefit in musculoskeletal disease. One focus is Osteoarthritis (OA), which affects around 8 million people in the UK alone. The research encompasses a greater understanding of the causes of musculoskeletal disease and the mechanism of action of therapy.
He is the Director of the Arthritis Research UK Tissue Engineering Centre. The £6 million Centre is based at four sites: Newcastle University, the University of Aberdeen, Keele University/the Robert Jones and Agnes Hunt Hospital NHS Foundation Trust in Oswestry and the University of York. Funded by a core grant of £2.4 million over five years from Arthritis Research UK with a further £3.4 million pledged by the four participating universities, the centre brings together leading clinicians, engineers and biologists from research and clinical groups. The aim and potential clinical impact is to treat early osteoarthritis by introducing stem cells into damaged joints in conjunction with exisiting surgical procedures. Prof McCaskie leads the Smart Step consortium (£1.1M) as part of Stage II UK Regenerative Medicine Platform. The aim is to develop cell-free approaches to Osteoarthritis and establish a translational pipeline for their development. He also facilitates Clinical Engagement as part of the Centre for Innovative Manufacturing in Medical Devices (MeDe) led by Leeds University.
Palmer AJR, Ayyar Gupta V, Fernquest S, Rombach I, Dutton SJ, Mansour R, Wood S, Khanduja V, Pollard TCB, McCaskie AW, Barker KL, Andrade TJMD, Carr AJ, Beard DJ, Glyn-Jones S; FAIT Study Group. Arthroscopic hip surgery compared with physiotherapy and activity modification for the treatment of symptomatic femoroacetabular impingement: multicentre randomised controlled trial. BMJ 2019 Jan 7;364:l185.
Zengini E, Hatzikotoulas K, Tachmazidou I, Steinberg J, Hartwig FP, Southam L, Hackinger S, Boer CG, Styrkarsdottir U, Gilly A, Suveges D, Killian B, Ingvarsson T, Jonsson H, Babis GC, McCaskie A, Uitterlinden AG, van Meurs JBJ, Thorsteinsdottir U, Stefansson K, Davey Smith G, Wilkinson JM, Zeggini E (2018) Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis. Nat Genet. 50(4):549-558.
Steinberg J, Brooks RA, Southam L, Bhatnagar S, Roumeliotis TI, Hatzikotoulas K, Zengini E, Wilkinson JM, Choudhary JS, McCaskie AW and Zeggini E. (2018) Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis. Rheumatology 1;57(8):1481-1489
Rodriguez-Fontenla C, Calaza M, Evangelou E, Valdes AM, Arden N, Blanco FJ, . . . Gonzalez A. (2014). Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies.. Arthritis Rheumatol, 66(4), 940-949.
Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD, Esko T . . . Valdes A M (2013). A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Annals of the Rheumatic Diseases 73(12);2130-6.
Zeggini E., Panoutsopoulou K., Southam L, Rayner NW, Day-Williams AG, Lopes MC, . . . Loughlin J. (2012). Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study. The Lancet 380(9844), 815-823.