Based at the Wolfson Brain Imaging Centre (WBIC) my research interests include the development and application of novel radiopharmaceuticals for application in the in vivo imaging technique of positron emission tomography (PET). As part of this I am Director of the RadioPharmaceutical Unit which manufacture these probes (e.g. for imaging hypoxia, inflammation and protein metabolism) under GMP for human studies at the WBIC and Addenbrooke’s PET-C Unit.
Li L, Brichard L, Larsen L, Menon DK, Smith RA, Murphy MP, Aigbirhio FI (2013) Radiosynthesis of 11-[(18) F] fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer. J Labelled Comp Radiopharm. Dec;56(14):717-21.
Fleming IN, Whelan M, Baxendale R, Gilbert FJ, Matthews PP, Aigbirhio FI (2012) Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers. Nucl Med Commun. Sep;33(9):899-906.
Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2014) Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study. Eur J Nucl Med Mol Imaging. 2014 Apr;41(4):736-44.
Burton TJ, Mackenzie IS, Balan K, Koo B, Bird N, Soloviev DV, Azizan EA, Aigbirhio F, Gurnell M, Brown MJ (2012) Evaluation of the sensitivity and specificity of (11)C-metomidate positron emission tomography (PET)-CT for lateralizing aldosterone secretion by Conn’s adenomas. J Clin Endocrinol Metab. Jan;97(1):100-9.
Porteous CM, Logan A, Evans C, Ledgerwood EC, Menon DK, Aigbirhio F, Smith RA, Murphy MP (2010) Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes. Biochim Biophys Acta. Sep;1800(9):1009-17.
Areas of expertise
PET radiochemistry , PET imaging