My research in musculoskeletal surgery focuses on the use of preclinical animal models, either naturally-occurring or induced. My major research themes include musculoskeletal oncology (bone cancer), implant fixation, regenerative strategies for enhancing bone healing, orthopaedic infection and retrieval analysis of orthopaedic implants. I am clinically active in the area of total joint replacement, with an emphasis on primary and revision total knee replacement. I am also very interested in developing translational research collaborations between the veterinary school and the medical school in the use of the small animal caseload to develop and evaluate new therapies for osteoarthritis, osteosarcoma and post-surgical pain. Our work is funded from a combination of governmental sponsors, private foundations and industry partners.
Baneux PJR, Martin ME, Allen MJ and Hallman TM. (2014) Issues related to Institutional Animal Care and Use Committees and clinical trials using privately owned animals. ILAR Journal. 55: 200-209.
Fahie MA, Ortolano GA, Guercio V, Schaffer JA, Johnston G, Au J, Hettlich H, Phillips T, Allen MJ and Bertone AL. (2013) Clinical outcome using Canine Platelet Enhancement Therapy (C-PET) for osteoarthritis: a prospective, double-blinded, controlled, multi-center study. Journal of the American Veterinary Medical Association. 243: 1291-1297.
Chaffee BK and Allen MJ. (2013) A clinically relevant mouse model of osteosarcoma with spontaneous metastasis. In Vivo 27: 599-603.
Mercurio AD, Motta T, Green E, Noble G, Hart RT and Allen MJ. (2012) Effects of extensive circumferential periosteal stripping on the microstructure and mechanical properties of the murine femoral cortex. Journal of Orthopaedic Research. 30: 561-568.
Lisle JL, Choi JY, Horton JA, Allen MJ and Damron TA. (2008) Metastatic osteosarcoma gene expression differs in vitro and in vivo. Clinical Orthopaedics and Related Research. 466: 2071-2080.
Arrington SA, Damron TA, Mann KA and Allen MJ. (2008) Concurrent administration of zoledronic acid and irradiation leads to improved bone density, biomechanical strength, and micro architecture in a mouse model of tumor-induced osteolysis.with zoledronic acid. Journal of Surgical Oncology. 97: 284-290.
Areas of expertise
animal model, implant fixation, histomorphometry, bone mechanics, osteolysis, bone cancer, infection, clinical trial, preclinical, biocompatibility, radiation therapy, osteosarcoma