My research focuses on the quantification of bone strength and architectural properties from clinical Quantitative Computed Tomography (QCT) scans. Specifically, I am adapting existing model fitting techniques to provide a measure of cortical porosity and endosteal activity over the cortical surface of the proximal femur.
The adapted model is validated against against High Resolution peripheral Quantitative CT (HR-pQCT) scans giving physical meaning to the model attributes. Once validated, the fracture prediction effectiveness of the model will be assessed using data from an existing prospective study of fracture risk. An interesting application of this research will be into the effect of various drugs on bone remodelling activity and structure.
Areas of expertise
electrical engineering, bioengineering, biomedical engineering